Hyperleucocytosis and Leucostasis in Acute Myeloid Leukaemia: A Challenging Clinical Situation

Mujahida Rahman(1), Munim Ahmed(2), Md. Kamrul Hasan(3)
(1) Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
(2) Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
(3) Colonel Maleque Medical College, Manikganj, Bangladesh

Abstract

Hyperleucocytosis is  defined as a white cell count (WBC) >50 x 109/L or commonly  100 x 109/L in a patient with leukaemia. Hyperleucocytosis with leucostasis is most often seen in patients with Acute Myeloid leukaemia (AML). AML with hyperleucocytosis is thought to have a poor prognosis because of a higher risk of early death due to complications such as disseminated intravascular coagulation (DIC), tumour lysis syndrome (TLS), and leucostasis, as well as a higher likelihood of long-term relapse. Leucostasis is considered a medical emergency since it has the potential to cause ischemia in vital organs with high mortality requiring immediate intervention. The molecular mechanisms that cause hyperleucocytosis are not well known.  The molecular mechanisms behind hyperleucocytosis remain poorly understood.

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Authors

Mujahida Rahman
Munim Ahmed
munim00@gmail.com (Primary Contact)
Md. Kamrul Hasan
Author Biographies

Mujahida Rahman, Bangabandhu Sheikh Mujib Medical University, Dhaka

Assistant Professor of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka

Munim Ahmed, Bangabandhu Sheikh Mujib Medical University, Dhaka

Assistant Professor of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka

Md. Kamrul Hasan, Colonel Maleque Medical College, Manikganj

Associate Professor of Haematology, Colonel Maleque Medical College, Manikganj

1.
Rahman M, Ahmed M, Hasan MK. Hyperleucocytosis and Leucostasis in Acute Myeloid Leukaemia: A Challenging Clinical Situation. Haematol J Bangladesh [Internet]. 2024 Feb. 20 [cited 2024 Apr. 17];8(1):39-46. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/127

Article Details

How to Cite

1.
Rahman M, Ahmed M, Hasan MK. Hyperleucocytosis and Leucostasis in Acute Myeloid Leukaemia: A Challenging Clinical Situation. Haematol J Bangladesh [Internet]. 2024 Feb. 20 [cited 2024 Apr. 17];8(1):39-46. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/127

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