Aberrant Expression of CD Markers in Acute Myeloid Leukaemia

Abul Kalam Azad(1), Md. Rafiquzzaman Khan(2), ABM Hasan Habib(3), Md. Abdul Wadud Miah (4), Masuda Begum(5)
(1) , Bangladesh
(2) Associate Professor of Haematology, Bangladesh
(3) , Bangladesh
(4) Assistant Professorof Pathology, Bangladesh
(5) Professor of Haematology, Bangladesh

Abstract

Background: Aberrant expression of cluster differentiation (CD) antigen marker is associated with poor outcome of acute leukaemia. Objective: Aim of this study is to determine the frequency and pattern of aberrant expression of CD markers in acute myeloid leukaemia patients in Bangladesh. Methods: This retrospective data analysis was conducted in the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) to assess the frequency of aberrant CD antigen expression in acute myeloid leukaemia from October 2016 to September 2017. During this period, we did one hundred flow cytometry of acute leukaemia patients and among them we found 48 acute myeloid Leukaemia (AML) who were included in this study. Result: Mean age of patients was 35 years (SD­ +14 years; Rang 3 to 50 years) with male: female ratio of 0.92. Four colour flow cytometry was done on fresh bone marrow aspirates and peripheral blood. Among 48 AML patients, aberrant CD expression was observed in 58% cases.  CD5 and cCD79a lymphoid markers were seen to be expressed in 32% cases of AML. Aberrant cCD3 and CD7 were expressed in 29% and 25% cases respectively and aberrant CD10, CD19, cCD22 were expressed in 11%, 3%, 3% cases acute myeloid leukaemia patients respectively. Conclusion: Aberrant CD antigen expression is not uncommon in AML patients of Bangladeshi population that may adversely affect the treatment outcome of the disease.

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Authors

Abul Kalam Azad
drswapon71@yahoo.com (Primary Contact)
Md. Rafiquzzaman Khan
ABM Hasan Habib
Md. Abdul Wadud Miah
Masuda Begum
Author Biographies

Abul Kalam Azad

Medical Officer, Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka

Md. Rafiquzzaman Khan, Associate Professor of Haematology

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka

ABM Hasan Habib

Medical Officer, Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka

Md. Abdul Wadud Miah , Assistant Professorof Pathology

Department of Pathology, Faridpur Medical college, Faridpur

Masuda Begum, Professor of Haematology

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka

1.
Azad AK, Khan MR, Habib AH, Miah MAW, Begum M. Aberrant Expression of CD Markers in Acute Myeloid Leukaemia. Haematol J Bangladesh [Internet]. 2020 May 13 [cited 2024 May 29];2(1):14-6. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/12

Article Details

How to Cite

1.
Azad AK, Khan MR, Habib AH, Miah MAW, Begum M. Aberrant Expression of CD Markers in Acute Myeloid Leukaemia. Haematol J Bangladesh [Internet]. 2020 May 13 [cited 2024 May 29];2(1):14-6. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/12

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