Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh

Saqi Md. Abdul Baqi(1), Umme Kulsum Munmun(2), Md. Rafiquzzaman Khan(3), Md. Salahuddin Shah(4), Shafiqul Islam(5), Farzana Rahman(6), Md. Abdul Aziz(7), Masuda Begum(8)
(1) , Bangladesh
(2) , Bangladesh
(3) , Bangladesh
(4) , Bangladesh
(5) , Bangladesh
(6) , Bangladesh
(7) , Bangladesh
(8) , Bangladesh

Abstract

Background: Cytogenetic analysis performed at diagnosis is considered to be the most important prognostic factor in AML. Objective: The purpose of this study was to observe the pattern of cytogenetic abnormalities in adult patients with de novo AML. Method: Total fifty-two newly diagnosed de novo AML patients were selected for the study. Six cytogenetic abnormalities including t(8;21), t(15;17), inv(16), BCR-ABL1, FLT3-ITD & NPM1 mutations were detected by Real-Time PCR. Results: In this study, 36 (69.2%) patients showed different cytogenetic abnormalities. The t(15;17) was found to be the most common. t(15;17), t(8;21) and inv(16) were found only in M3, M2 and M4 FAB subtypes, respectively. Significant association was found with increasing age and cytogenetic risk groups. BCR-ABL1 mutation showed significant relation with increased age. FLT3-ITD mutation showed significant association with increased WBC count and inv16 was significantly associated with relatively less bone marrow blast percentage. Conclusion: Cytogenetic study should be performed routinely in all cases of AML for proper diagnosis, prediction of prognosis and implementation of effective therapeutic measures.

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Authors

Saqi Md. Abdul Baqi
saqi.dmc@gmail.com (Primary Contact)
Umme Kulsum Munmun
Md. Rafiquzzaman Khan
Md. Salahuddin Shah
Shafiqul Islam
Farzana Rahman
Md. Abdul Aziz
Masuda Begum
Author Biographies

Saqi Md. Abdul Baqi

Medical Officer, Department of Haematology & BMT, Dhaka Medical College Hospital, Dhaka

Umme Kulsum Munmun

Lecturer, Department of pathology, Dhaka medical college

Md. Rafiquzzaman Khan

Associate Professor, Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Md. Salahuddin Shah

Associate Professor, Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Shafiqul Islam

Medical Officer, Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Farzana Rahman

Assistant Professor, Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Md. Abdul Aziz

Professor of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Masuda Begum

Professor of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

1.
Baqi SMA, Munmun UK, Khan MR, Shah MS, Islam S, Rahman F, et al. Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh. Haematol J Bangladesh [Internet]. 2020 Jun. 20 [cited 2024 May 29];4(1):08-12. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/47

Article Details

How to Cite

1.
Baqi SMA, Munmun UK, Khan MR, Shah MS, Islam S, Rahman F, et al. Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh. Haematol J Bangladesh [Internet]. 2020 Jun. 20 [cited 2024 May 29];4(1):08-12. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/47

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