A Case Report: Autoimmune Haemolytic Anaemia & Paroxysmal Nocturnal Haemoglobinuria Association

Fatima- Tuz- Zohra (1) , Abu Hasan Rubel (2) , Mohd. Tariqul Islam (3) , Md. Sirazul Islam (4)
(1) Asgar Ali Hospital , Bangladesh
(2) Asgar Ali Hospital , Bangladesh
(3) Asgar Ali Hospital , Bangladesh
(4) Asgar Ali Hospital , Bangladesh

Abstract

Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs’ test is positive in cases of immune-mediated haemolytic anaemia and, thus, is positive in AIHA but negative in PNH. We report a case of a man presenting with a haemolytic anaemia who was found to have concomitant evidence of AIHA and PNH. The case highlights the importance of carrying out a comprehensive haemolysis work-up in patients who present with haemolytic anaemia. 

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Authors

Fatima- Tuz- Zohra
dr.mou.heart@gmail.com (Primary Contact)
Abu Hasan Rubel
Mohd. Tariqul Islam
Md. Sirazul Islam
Author Biographies

Fatima- Tuz- Zohra, Asgar Ali Hospital

Specialist, Lab Medicine Department, Asgar Ali Hospital, Dhaka

Abu Hasan Rubel, Asgar Ali Hospital

Specialist, Haematology Department, Asgar Ali Hospital, Dhaka

Mohd. Tariqul Islam, Asgar Ali Hospital

Senior Consultant, Pathology & Laboratory Medicine, Asgar Ali Hospital, Dhaka

Md. Sirazul Islam, Asgar Ali Hospital

Senior Consultant, Haematopathology & Lab Medicine, Asgar Ali Hospital, Dhaka

1.
Zohra F-T-, Rubel AH, Islam MT, Islam MS. A Case Report: Autoimmune Haemolytic Anaemia & Paroxysmal Nocturnal Haemoglobinuria Association. Haematol J Bangladesh [Internet]. 2024 Feb. 14 [cited 2024 Feb. 28];7(1):44-7. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/91

Article Details

How to Cite

1.
Zohra F-T-, Rubel AH, Islam MT, Islam MS. A Case Report: Autoimmune Haemolytic Anaemia & Paroxysmal Nocturnal Haemoglobinuria Association. Haematol J Bangladesh [Internet]. 2024 Feb. 14 [cited 2024 Feb. 28];7(1):44-7. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/91