Chronic Lymphocytic Leukaemia Complicated by Cranial Diabetes Insipidus - A Case Report

Authors

  • Sharmin Mafruha Bangabandhu Sheikh Mujub Medical University, Dhaka
  • Khaza Amirul Islam https://orcid.org/0000-0002-2625-9542
  • Ishwor Mansingh Bangabandhu Sheikh Mujub Medical University, Dhaka
  • Md. Arif-Ur- Rahman Bangabandhu Sheikh Mujub Medical University, Dhaka https://orcid.org/0000-0001-9347-9767
  • Menoti Paul Bangabandhu Sheikh Mujub Medical University, Dhaka
  • Tanjin Tabassum Mitu Bangabandhu Sheikh Mujub Medical University, Dhaka

DOI:

https://doi.org/10.37545/haematoljbd202170

Keywords:

Chronic lymphocytic leukaemia, Polyuria, Polydipsia, Diabetes Insipidus, Leukaemic infiltration, Water deprivation test

Abstract

Here we describe a case of 55-year-old lady who was admitted in hospital for evaluation of recurrent anaemia, polyuria and polydipsia with history of splenectomy 9 months back. Physical examination revealed anaemia, dehydration and scar mark of splenectomy. Initial laboratory tests were suggestive of chronic lymphocytic leukaemia (CLL) and further bone marrow examination & immunophenotyping confirmed the diagnosis. At the same time Polyuria & polydipsia was evaluated by water deprivation test and diabetes insipidus was diagnosed.

Author Biographies

Sharmin Mafruha, Bangabandhu Sheikh Mujub Medical University, Dhaka

Bangabandhu Sheikh Mujub Medical University, Dhaka

Ishwor Mansingh, Bangabandhu Sheikh Mujub Medical University, Dhaka

Bangabandhu Sheikh Mujub Medical University, Dhaka

Md. Arif-Ur- Rahman, Bangabandhu Sheikh Mujub Medical University, Dhaka

Bangabandhu Sheikh Mujub Medical University, Dhaka

Menoti Paul, Bangabandhu Sheikh Mujub Medical University, Dhaka

Bangabandhu Sheikh Mujub Medical University, Dhaka

Tanjin Tabassum Mitu, Bangabandhu Sheikh Mujub Medical University, Dhaka

Bangabandhu Sheikh Mujub Medical University, Dhaka

References

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Miller VI, Campbell Jr WG. Diabetes insipidus as a complication of leukemia: A case report with a literature review. Cancer. 1971 Sep;28(3):666-73.

Watanabe N, Takahashi T, Sugimoto N, Tanaka Y, Kurata M, Matsushita A, Maeda A, Nagai K, Nasu K. Excellent response of chemotherapy-resistant B-cell-type chronic lymphocytic leukemia with meningeal involvement to rituximab. International journal of clinical oncology. 2005 Oct 1;10(5):357-61.

Hanse MC, Van’t Veer MB, van Lom K, Van den Bent MJ. Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment. Journal of neurology. 2008 Jun 1;255(6):828.

Robertson GL. Diabetes insipidus. Endocrinology and metabolism clinics of North America. 1995 Sep 1;24(3):549-72.

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Published

06.05.2021

How to Cite

1.
Mafruha S, Islam KA, Mansingh I, Rahman MA-U-, Paul M, Mitu TT. Chronic Lymphocytic Leukaemia Complicated by Cranial Diabetes Insipidus - A Case Report. Haematol J Bangladesh [Internet]. 2021 May 6 [cited 2021 Oct. 19];5(01):42-3. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/70

Issue

Section

Case Report(s)