Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients

Md. Shafiul Azam (1) , Khaza Amirul Islam (2) , Sharmin Mafruha (3) , Mirza Golam Sarwar (4) , Md. Salahuddin Shah (5) , Md. Abdul Aziz (6)
(1) , Bangladesh
(2) , Bangladesh
(3) , Bangladesh
(4) , Bangladesh
(5) , Bangladesh
(6) , Bangladesh

Abstract

Background: BCR-ABL translocation is the most common genetic abnormality associated with adult Acute Lymphoblastic Leukaemia (ALL) with poor outcome. Objective: The aim of the study was to determine the association of myeloid aberrant antigens and the presence of BCR-ABL gene rearrangements in acute lymphoblastic leukaemia (ALL) patients in our context. Method: A total of 38 ALL patients were included in this cross-sectional study from August 2018 to July 2019 according to selection criteria. BCR-ABL was detected by Real Time-Polymerase Chain Reaction (RT-PCR). Results: The median age at diagnosis was 27.5 years with male (76.3%) predominance. Aberrant myeloid markers, e.g.CD13 was present in 9(64.3%) patients who were BCR-ABL positive which was statistically significant (p:<0.05). Conclusion: Early suspicion about BCR-ABL positivity can be made in ALL patients who show aberrant myeloid expression.

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Authors

Md. Shafiul Azam
dr.azam05@yahoo.com (Primary Contact)
Khaza Amirul Islam
Sharmin Mafruha
Mirza Golam Sarwar
Md. Salahuddin Shah
Md. Abdul Aziz
Author Biographies

Md. Shafiul Azam

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

Khaza Amirul Islam

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

Sharmin Mafruha

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

Mirza Golam Sarwar

Department of Medicine, Dhaka Dental College, Mirpur, Dhaka, Bangladesh

Md. Salahuddin Shah

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

Md. Abdul Aziz

Department of Haematology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

1.
Azam MS, Islam KA, Mafruha S, Sarwar MG, Shah MS, Aziz MA. Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients. Haematol J Bangladesh [Internet]. 2020 Jun. 20 [cited 2024 Mar. 29];4(1):13-5. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/60

Article Details

How to Cite

1.
Azam MS, Islam KA, Mafruha S, Sarwar MG, Shah MS, Aziz MA. Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients. Haematol J Bangladesh [Internet]. 2020 Jun. 20 [cited 2024 Mar. 29];4(1):13-5. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/60