Congenital Langerhans Cell Histiocytosis Presenting as Neonatal Papulovesicular Eruption Rapid Recurrence with Multisystem Involvement after Spontaneous Regression of Primary Lesion

Abstract

Congenital self-healingLangerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period. It is usually characterized by the eruption of multiple, discrete, red-brown papules or nodules which may increase in size and number during the first few weeks of life with spontaneous regression.Congenital LCH has rarely been reported to present as a papulovesicular eruption at birth. Here we describe a male baby presenting   with papulovesicular eruption at birth who rapidly developed pulmonary infiltrates and multiple osteolytic lesions in skull and long bones after spontaneous regression of cutaneous lesion.