Bacterial Pattern and Susceptibility of Antimicrobial Agents in Cancer Patient with Infection

Md. Kamrul Hasan (1) , Mamtaz Begum (2) , Bilkis Ara Begum (3) , Md. Johirul Islam (4) , Saima Easin (5) , Moushumi Sarker (6) , Abu Jafar Siddique (7)
(1) , Bangladesh
(2) , Bangladesh
(3) , Bangladesh
(4) , Bangladesh
(5) , Bangladesh
(6) , Bangladesh
(7) , Bangladesh

Abstract

Introduction: Cancer patients are most vulnerable to develop infection during anticancer therapy which could be life threatening. Therefore, prompt administration of appropriate antimicrobial drug therapy is often essential to prevent mortality and morbidity in such patients. Spectrum of the infection causing organisms is continuously changing throughout the world along with their susceptibility to antimicrobials drugs. Aims: The aims of the study were to identify the bacterial pattern and their susceptibility to antimicrobials in cancer patients with infection and to help develop a guideline for the rational and appropriate use of antimicrobial in these patients. Materials and methods: It was an observational study conducted from January 2013 to December 2014 at the National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka. We evaluated 517 blood and other specimens from cancer patients of both sexes and all ages under anticancer therapy suspected of having infection. Result: Blood culture was done in 53 patients of them 8 (15.09%) were proved to be culture positive. In case of urine and wound culture the rates of positivity were 37.79% & 73.98% respectively. In suspected cases culture for anaerobic organism was done but no such organism was found. Major isolated organisms in different cultures were E. coli, Staphylococcus aureus, Pseudomonas and Proteus. Imipenem, gentamicin, cotrimoxazole were the most sensitive antibiotics. However, in most cases amoxicillin, cephalexin and nalidixic acid were mostly resistant. Conclusion: Empirical use of amoxicillin or cephalexin is usually not useful and routine use of anaerobic culture is not necessary.

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Authors

Md. Kamrul Hasan
akndkamrul@gmail.com (Primary Contact)
Mamtaz Begum
Bilkis Ara Begum
Md. Johirul Islam
Saima Easin
Moushumi Sarker
Abu Jafar Siddique
Author Biographies

Md. Kamrul Hasan

Assistant Professor of Haematology, Colonel Malek Medical College, Manikganj

Mamtaz Begum

Professor of Paediatric Oncology, National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka 1212

Bilkis Ara Begum

Associate Professor of Microbiology, National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka 1212

Md. Johirul Islam

Associate Professor of Cancer Epidemiology Department, NICRH, Dhaka 1212

Saima Easin

Assistant Professor of Microbiology, National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka 1212

Moushumi Sarker

Assistant Professor of Microbiology, National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka 1212

Abu Jafar Siddique

Medical Technologist, Department of Microbiology, NICRH, Dhaka 1212

1.
Hasan MK, Begum M, Begum BA, Islam MJ, Easin S, Sarker M, et al. Bacterial Pattern and Susceptibility of Antimicrobial Agents in Cancer Patient with Infection. Haematol J Bangladesh [Internet]. 2020 May 13 [cited 2024 Mar. 29];2(2):33-8. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/20

Article Details

How to Cite

1.
Hasan MK, Begum M, Begum BA, Islam MJ, Easin S, Sarker M, et al. Bacterial Pattern and Susceptibility of Antimicrobial Agents in Cancer Patient with Infection. Haematol J Bangladesh [Internet]. 2020 May 13 [cited 2024 Mar. 29];2(2):33-8. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/20