Antimicrobial Sensitivity Pattern of Bacteria Isolated from Urine in a Pediatric Hematology Oncology Department: A Single Institutional Study

Md. Tanvir Ahammed(1), S. M. Rezanur Rahman(2), Md. Lutfor Rahman Mollah(3), Mehnaz Akter(4), Zannat Ara (5), Md. Bani Yeamin(6), Md. Tariqul Islam(7), Mohammad Majharul Islam(8), Roksana Akter(9)
(1) Dhaka Medical College, Dhaka, Bangladesh
(2) Dhaka Medical College, Dhaka, Bangladesh
(3) Sir Salimullah Medical College, Dhaka, Bangladesh
(4) Dhaka Medical College, Dhaka, Bangladesh
(5) Dhaka Medical College, Dhaka, Bangladesh
(6) Mymensingh Medical College Hospital, Mymensingh, Bangladesh
(7) Sir Salimullah Medical College, Dhaka, Bangladesh
(8) Patuakhali Medical College, Patuakhali, Bangladesh
(9) Dhaka Medical College, Dhaka, Bangladesh

Abstract

Background: Urinary tract infections (UTIs) may present with nonspecific symptoms and without any definitive clinical signs other than fever, hence may be missed without a routine urine analysis. We prospectively evaluated all cases of culture-positive urine infections in pediatric hematology oncology department of Dhaka Medical College Hospital (DMCH). Materials and methods: All positive urine culture incidents for pediatric cancer patients receiving treatment during the year July 2020 to August 2022 were included in this study. Analysis was performed on patients with regards to clinical, microbiology and pertinent lab findings. Results: There were 24 episodes of documented positive urine cultures among 17 patients. Most of the patients were febrile on the day of culture (87.5%) Majority of positive urine cultures were found in solid tumor patients (54.17%). Most commonly detected organisms were Gram-negative (91.67%), with E.coli being the most frequent (62.5%), followed by klebsiella (16.66%). Colistin sulphate, tigecycline, nitrofurantoin, meropenem were the most sensitive against Gram negative bacteria and the entire isolated Gram positive bacteria were 100% sensitive to amoxicillin, vancomycin, linezolid and nitrofurantoin. Conclusions: Positive urine culture in children with cancer sometimes may not be associated with urinalysis abnormalities only. When selecting empiric treatment for cancer patients with UTIs, one should take into consideration the institutional antibiotic sensitivity pattern.

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Authors

Md. Tanvir Ahammed
tanvir.bsmmu@gmail.com (Primary Contact)
S. M. Rezanur Rahman
Md. Lutfor Rahman Mollah
Mehnaz Akter
Zannat Ara
Md. Bani Yeamin
Md. Tariqul Islam
Mohammad Majharul Islam
Roksana Akter
Author Biographies

Md. Tanvir Ahammed, Dhaka Medical College, Dhaka

Assistant Professor, Department of Paediatric Haematology and Oncology, Dhaka Medical College, Dhaka

S. M. Rezanur Rahman, Dhaka Medical College, Dhaka

Assistant Professor, Department of Paediatric Haematology and Oncology, Dhaka Medical College, Dhaka

Md. Lutfor Rahman Mollah, Sir Salimullah Medical College, Dhaka

Assistant Professor, Department of Pediatric Hematology and Oncology, Sir Salimullah Medical College, Dhaka

Mehnaz Akter, Dhaka Medical College, Dhaka

Assistant Professor, Department of Paediatric Haematology and Oncology, Dhaka Medical College, Dhaka

Zannat Ara , Dhaka Medical College, Dhaka

Assistant Professor, Department of Paediatric Haematology and Oncology, Dhaka Medical College, Dhaka

Md. Bani Yeamin, Mymensingh Medical College Hospital, Mymensingh

Assistant Professor, Department of Pediatric Hematology and Oncology, Mymensingh Medical College Hospital, Mymensingh

Md. Tariqul Islam, Sir Salimullah Medical College, Dhaka

Assistant Professor, Department of Neonatology, Sir Salimullah Medical College, Dhaka

Mohammad Majharul Islam, Patuakhali Medical College, Patuakhali

Assistant Professor, Department of Pediatric Nephrology, Patuakhali Medical College, Patuakhali

Roksana Akter, Dhaka Medical College, Dhaka

Resident (Pathology), Dhaka Medical College, Dhaka

1.
Ahammed MT, Rahman SMR, Mollah MLR, Akter M, Ara Z, Yeamin MB, et al. Antimicrobial Sensitivity Pattern of Bacteria Isolated from Urine in a Pediatric Hematology Oncology Department: A Single Institutional Study. Haematol J Bangladesh [Internet]. 2023 Dec. 31 [cited 2024 Apr. 17];7(2):61-7. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/103

Article Details

How to Cite

1.
Ahammed MT, Rahman SMR, Mollah MLR, Akter M, Ara Z, Yeamin MB, et al. Antimicrobial Sensitivity Pattern of Bacteria Isolated from Urine in a Pediatric Hematology Oncology Department: A Single Institutional Study. Haematol J Bangladesh [Internet]. 2023 Dec. 31 [cited 2024 Apr. 17];7(2):61-7. Available from: https://journal.hematologybd.org/index.php/haematoljbd/article/view/103
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